BDBM50660331 CHEMBL6171119
SMILES O=C(Cn1nc(C(=O)Nc2cccnc2)c2ccccc21)Nc1ccc(Cl)cc1
InChI Key InChIKey=UFBJGQYTURJBIM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50660331
TargetSolute carrier organic anion transporter family member 2B1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 155nMAssay Description:Inhibition of OATP2B1 (unknown origin) transfected in human A-431 cells assessed as inhibition of pyranine uptake preincubated for 5 mins followed by...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1A2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 422nMAssay Description:Inhibition of OATP1A2 (unknown origin) transfected in human A-431 cells assessed as inhibition of SR101 uptake preincubated for 5 mins followed by SR...More data for this Ligand-Target Pair
Ligand Info
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataEC50: 1.05E+3nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance transfected in dog MDCK-II-BCRP cells assessed as increase in SN-38-mediated cytotox...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1B3(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of OATP1B3 (unknown origin) transfected in human A-431 cells assessed as inhibition of DHPDS uptake preincubated for 5 mins followed by DH...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ABCC1 in human NCI-H69AR cells assessed as increase in rhodamine123 fluorescence intensity using rhodamine123 as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetMonocarboxylate transporter 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibition of MCT-1 in human A549 cells assessed as potentiation of 3-BP-mediated cytotoxicity by measuring decrease in cell viability incubated for ...More data for this Ligand-Target Pair
Ligand Info
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataEC50: 4.67E+3nMAssay Description:Reversal of ABCB1-mediated multidrug resistance in human A2780 ADR cells assessed as increase in doxorubicin-mediated cytotoxicity incubated for 72 h...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 5.15E+3nMAssay Description:Inhibition of ABCC1 in human NCI-H69AR cells assessed as increase in daunorubicin fluorescence intensity using daunorubicin as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 6.12E+3nMAssay Description:Inhibition of ABCB1 in human A2780 ADR cells assessed as increase in calcein-AM fluorescence intensity using calcein-AM as tracer preincubated for 30...More data for this Ligand-Target Pair
Ligand Info
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 6.56E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells assessed as increase in Hoechst 33342 fluorescence intensity using Hoechst 3...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataEC50: 6.86E+3nMAssay Description:Reversal of ABCC1-mediated multidrug resistance in human NCI-H69AR cells assessed as increase in doxorubicin-mediated cytotoxicity incubated for 72 h...More data for this Ligand-Target Pair
Ligand Info
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of ABCB1 in human A2780 ADR cells assessed as increase in daunorubicin fluorescence intensity using daunorubicin as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells assessed as increase in pheophorbide A fluorescence intensity using pheophor...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1B1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.79E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin) transfected in human A-431 cells assessed as inhibition of DHPDS uptake preincubated for 5 mins followed by DH...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier family 22 member 2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 6.01E+4nMAssay Description:Inhibition of OCT2 (unknown origin) expressed in HEK293 cells assessed as inhibition of ASP+ uptake incubated for 5 mins by fluorescence based analys...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier family 22 member 3(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.11E+5nMAssay Description:Inhibition of OCT3 (unknown origin) expressed in HEK293 cells assessed as inhibition of ASP+ uptake incubated for 5 mins by fluorescence based analys...More data for this Ligand-Target Pair
Ligand Info