BDBM50660334 CHEMBL6146403

SMILES COc1cccc(NC(=O)Cn2nc(C(=O)Nc3cccc(OC)c3)c3ccccc32)c1

InChI Key InChIKey=OUIIWSBYPHAYQP-UHFFFAOYSA-N

Data  11 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50660334   

TargetSolute carrier organic anion transporter family member 1A2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 420nMAssay Description:Inhibition of OATP1A2 (unknown origin) transfected in human A-431 cells assessed as inhibition of SR101 uptake preincubated for 5 mins followed by SR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSolute carrier organic anion transporter family member 2B1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 583nMAssay Description:Inhibition of OATP2B1 (unknown origin) transfected in human A-431 cells assessed as inhibition of pyranine uptake preincubated for 5 mins followed by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ABCB1 in human A2780 ADR cells assessed as increase in calcein-AM fluorescence intensity using calcein-AM as tracer preincubated for 30...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells assessed as increase in pheophorbide A fluorescence intensity using pheophor...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of ABCB1 in human A2780 ADR cells assessed as increase in daunorubicin fluorescence intensity using daunorubicin as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of ABCC1 in human NCI-H69AR cells assessed as increase in daunorubicin fluorescence intensity using daunorubicin as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataEC50:  2.01E+3nMAssay Description:Reversal of ABCB1-mediated multidrug resistance in human A2780 ADR cells assessed as increase in doxorubicin-mediated cytotoxicity incubated for 72 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells assessed as increase in Hoechst 33342 fluorescence intensity using Hoechst 3...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSolute carrier organic anion transporter family member 1B3(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of OATP1B3 (unknown origin) transfected in human A-431 cells assessed as inhibition of DHPDS uptake preincubated for 5 mins followed by DH...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 2.66E+3nMAssay Description:Inhibition of ABCC1 in human NCI-H69AR cells assessed as increase in rhodamine123 fluorescence intensity using rhodamine123 as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 4.96E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin) transfected in human A-431 cells assessed as inhibition of DHPDS uptake preincubated for 5 mins followed by DH...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataEC50:  8.55E+3nMAssay Description:Reversal of ABCC1-mediated multidrug resistance in human NCI-H69AR cells assessed as increase in doxorubicin-mediated cytotoxicity incubated for 72 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSolute carrier family 22 member 2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660334BDBM50660334(CHEMBL6146403)
Affinity DataIC50: 2.08E+4nMAssay Description:Inhibition of OCT2 (unknown origin) expressed in HEK293 cells assessed as inhibition of ASP+ uptake incubated for 5 mins by fluorescence based analys...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed