BDBM50660658 CHEMBL6169764

SMILES CC#CCn1cc(N(C)c2nc(C(N)=O)c(-c3cc(C(=O)N(C)C)c[nH]3)s2)cn1

InChI Key InChIKey=NRQJEMDYHYCNFH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50660658   

TargetTGF-beta receptor type-1(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660658BDBM50660658(CHEMBL6169764)
Affinity DataIC50: 43nMAssay Description:Inhibition of ALK5 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetAurora kinase C(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660658BDBM50660658(CHEMBL6169764)
Affinity DataIC50: 168nMAssay Description:Inhibition of Aurora Kinase C (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMothers against decapentaplegic homolog 3(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660658BDBM50660658(CHEMBL6169764)
Affinity DataIC50: 300nMAssay Description:Inhibition of TGFbeta-stimulated SMAD3 phosphorylation in human A549 cells preincubated for 1 hrs followed by human TGF-beta1 addition and measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Carna Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660658BDBM50660658(CHEMBL6169764)
Affinity DataIC50: 322nMAssay Description:Inhibition of TrkC (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed