BDBM50660680 CHEMBL6146175

SMILES COc1cc(-c2cc(-c3cnn(C4CCOCC4)c3)cnc2N)cc(OC(F)F)c1C(=O)NC1CC1

InChI Key InChIKey=WVJLEXKNGVZDAH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50660680   

TargetSerine/threonine-protein kinase SIK2(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660680BDBM50660680(CHEMBL6146175)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant full length human SIK2 assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by micropla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660680BDBM50660680(CHEMBL6146175)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human SIK3 assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by microplate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660680BDBM50660680(CHEMBL6146175)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human SIK1 (02 to 131) assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by microplate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed