BDBM50660869 CHEMBL6152797

SMILES Cc1cc2cc(ccc2nc1N)C(=O)N(Cc3ccc(cn3)C(F)(F)F)CC(C)C

InChI Key InChIKey=CSGBHAZUAYOHGC-UHFFFAOYSA-N

Data  1 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50660869   

LigandChemical structure of BindingDB Monomer ID 50660869BDBM50660869(CHEMBL6152797)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) preincubated with compound for 24 hrs in presence of SAM and MTA followed by Histone H4 (1-21)-Lys(Biotin)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50660869BDBM50660869(CHEMBL6152797)
Affinity DataIC50: 35nMAssay Description:Inhibition of human PRMT5/MEP50 using Histone H2A as substrate preincubated for 1 hr in presence of SAM/MTA followed by substrate addition and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50660869BDBM50660869(CHEMBL6152797)
Affinity DataIC50: 37nMAssay Description:Inhibition of human PRMT5/MEP50 using Histone H2A as substrate preincubated for 1 hr in presence of SAM followed by substrate addition and measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)