BDBM50662330 CHEMBL6162165

SMILES CCn1c(cc(n1)C(=O)Nc2cccc(c2)NS(=O)(=O)C)C

InChI Key InChIKey=RNCRRFDHODBLRY-UHFFFAOYSA-N

Data  1 IC50  2 Kd  2 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50662330   

TargetATP-dependent RNA helicase A(Human)
Accent Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662330BDBM50662330(CHEMBL6162165)
Affinity DataKd:  330nMAssay Description:Binding affinity to human DHX9 assessed as dissociation constant measured for 360 sec by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent RNA helicase A(Human)
Accent Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662330BDBM50662330(CHEMBL6162165)
Affinity DataKd:  400nMAssay Description:Binding affinity to human DHX9 assessed as dissociation constant measured for 360 sec in presence of ATP by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent RNA helicase A(Human)
Accent Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662330BDBM50662330(CHEMBL6162165)
Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of human DHX9 using double-stranded RNA and ATP as substrate pre-incubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent RNA helicase A(Human)
Accent Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662330BDBM50662330(CHEMBL6162165)
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of human DHX9 using split-beacon oligonucleotide and ATP as substrate pre-incubated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent RNA helicase A(Human)
Accent Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662330BDBM50662330(CHEMBL6162165)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of DHX9 in human PBMC assessed as target engagement by measuring circBRIP1 incubated for 24 hrs by Taqman qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)