BDBM50663150 CHEMBL6172734

SMILES COc1ccc(NC(=O)c2cc(N)cc(Nc3ccc4[nH]cc(C#N)c4c3)c2)cc1

InChI Key InChIKey=PROPOTQWIMVSMQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50663150   

TargetBDNF/NT-3 growth factors receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663150BDBM50663150(CHEMBL6172734)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of TRKB (unknown origin) using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins by HTRF ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663150BDBM50663150(CHEMBL6172734)
Affinity DataIC50: 6nMAssay Description:Inhibition of wild type TRKA (unknown origin) using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 90 min...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663150BDBM50663150(CHEMBL6172734)
Affinity DataIC50: 25nMAssay Description:Inhibition of TRKC (unknown origin) using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins by HTRF ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663150BDBM50663150(CHEMBL6172734)
Affinity DataIC50: 123nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 90 ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed