BDBM50663424 CHEMBL6175025

SMILES C=CC(=O)N1CCN(c2nc(=O)n(-c3c(C)ccnc3C(C)C)c3nc(-c4c(O)cccc4F)c(F)cc23)[C@H](C)C1

InChI Key InChIKey=NXQKSXLFSAEQCZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50663424   

TargetGTPase KRas(Human)
Jacobio Pharmaceuticals Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663424BDBM50663424(CHEMBL6175025)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of His-tagged GDP-loaded KRAS G12C mutant (unknown origin) assessed as SOS1-mediated guanine nucleotide exchange preincubated with compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed