BDBM50663847 CHEMBL6162316

SMILES Cc1nn([C@H]2C[C@H](C)N(C)C2)cc1-c1cnc(Nc2ccnc(-c3cnn(S(=O)(=O)C4CC4)c3)n2)cc1OC(C)C

InChI Key InChIKey=SLLTYDHMZCFPRI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50663847   

TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663847BDBM50663847(CHEMBL6162316)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of EGFR de119/T790M/C797S mutant (694 to 1022 residues)(unknown origin) using BML-P243 as substrate incubated for 90 mins in presence of A...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Daiichi Sankyo Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663847BDBM50663847(CHEMBL6162316)
Affinity DataIC50: 66nMAssay Description:Inhibition of N-terminal GST-tagged wild-type human EGFR (669 to 1210 residues) expressed in Sf21 cells using BML-P243 as substrate incubated for 90 ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed