BDBM50664063 CHEMBL6172131

SMILES Cc1ccncc1-c1cc(N)c2cnc(NC(=O)[C@@H]3C[C@H]3C#N)cc2c1

InChI Key InChIKey=DKSAUTCUJKILFS-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50664063   

LigandChemical structure of BindingDB Monomer ID 50664063BDBM50664063(CHEMBL6172131)
Affinity DataEC50:  186nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50664063BDBM50664063(CHEMBL6172131)
Affinity DataIC50: 280nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed