BDBM50664102 CHEMBL6162327

SMILES COc1ccc(CN2C3CC2CN(c2ccc(-c4nc(-c5cnn(C)c5)cc5ncccc45)cn2)C3)cn1

InChI Key InChIKey=XDWABLGMKLWZGH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50664102   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664102BDBM50664102(CHEMBL6162327)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of RET V804L mutant (unknown origin) by FRET-based ZLyte kinase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664102BDBM50664102(CHEMBL6162327)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of RET M918T mutant (unknown origin) by FRET-based ZLyte kinase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664102BDBM50664102(CHEMBL6162327)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of wild type RET (unknown origin) by FRET-based ZLyte kinase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664102BDBM50664102(CHEMBL6162327)
Affinity DataIC50: 56nMAssay Description:Inhibition of RET G810R mutant (unknown origin) by FRET-based ZLyte kinase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed