BDBM50664673 CHEMBL6149651

SMILES COc1cc(N(C)CCN(C)C)c2cc1Nc1ncc(C(F)(F)F)c(n1)Nc1ccc(cc1P(C)(C)=O)OCCCCC(=O)N2

InChI Key InChIKey=KZIYPKTXHKCVHR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50664673   

TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664673BDBM50664673(CHEMBL6149651)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human EGFR T790M/L858R mutant (696 to end residues) extracted from baculovirus infect Sf21 insect cel...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664673BDBM50664673(CHEMBL6149651)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human EGFR 19del/T790M/C797S mutant (668 to end residues) extracted from Sf9 insect cells incubated f...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664673BDBM50664673(CHEMBL6149651)
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant C-terminal His-tagged/N-terminal GST-tagged human EGFR T790M/C797S/L858R mutant (668 to 1210 residues) extracted from bacul...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664673BDBM50664673(CHEMBL6149651)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant wildtype N-terminal GST-tagged human EGFR kinase domain (696 to end residues) extracted from baculovirus infect Sf21 insect...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed