BDBM50666690 CHEMBL6174564

SMILES Cc1c(ocn1)COc2ccc3c(c2)CN[C@@H](C3)[C@@H](CNC(=O)c4cc(nc(n4)N5CCC(CC5)C)NC6CN(C6)C(=O)C)O

InChI Key InChIKey=YORKMGQSIAFLDS-UHFFFAOYSA-N

Data  3 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50666690   

LigandChemical structure of BindingDB Monomer ID 50666690BDBM50666690(CHEMBL6174564)
Affinity DataKi: <4nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) using TAMRA-labeled histone H4 peptide as substrate in presence of MTA by fluorescence anisotropy peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50666690BDBM50666690(CHEMBL6174564)
Affinity DataKi:  30nMAssay Description:Inhibition of apo-PRMT5/MEP50 (unknown origin) using TAMRA-labeled histone H4 peptide as substrate by fluorescence anisotropy peptide displacement as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Tango Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666690BDBM50666690(CHEMBL6174564)
Affinity DataIC50: 30nMAssay Description:Inhibition of PRMT5 in MTAP-null human HAP1 cells assessed as reduction in SDMA level incubated for 24 hrs by in-cell western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50666690BDBM50666690(CHEMBL6174564)
Affinity DataKi:  70nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) using TAMRA-labeled histone H4 peptide as substrate in presence of SAM by fluorescence anisotropy peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)