BDBM50666717 CHEMBL6176278

SMILES CN1CCC[C@@H](Nc2nnc(-c3ccc(C(F)(F)F)cc3O)c3c2CCC3)C1

InChI Key InChIKey=RNMZAJDQUZRCLD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50666717   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666717BDBM50666717(CHEMBL6176278)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of NLRP3 in LPS-induced human PBMC cells assessed as inhibition of IL-1beta secretion pretreated with compound for 30 mins followed by LPS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666717BDBM50666717(CHEMBL6176278)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of NLRP3 in LPS/Nigericin induced human CD14-positive cell assessed as inhibition of caspase-1 level pretreated with compound followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666717BDBM50666717(CHEMBL6176278)
Affinity DataIC50: 68nMAssay Description:Inhibition of LPS-induced NLRP3 in human whole blood pretreated with LPS for 1 hr followed by compound addition and measured after 30 mins by MSD ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666717BDBM50666717(CHEMBL6176278)
Affinity DataIC50: 320nMAssay Description:Inhibition of NLRP3 ATPase (unknown origin) by ADP-Glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666717BDBM50666717(CHEMBL6176278)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of NLRP3 in LPS-induced human PBMC cells assessed as inhibition of TNF-alpha secretion pretreated with compound for 30 mins followed by LP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
A Johnson & Johnson Company

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666717BDBM50666717(CHEMBL6176278)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRP3 in LPS-induced human PBMC cells assessed as inhibition of IL-6 secretion pretreated with compound for 30 mins followed by LPS sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed