BDBM50666851 CHEMBL6176040

SMILES C=CC(=O)N1CCc2c(ncnc2N2CC[C@@H](Nc3ncc(Cl)c(OC)n3)C2)C1

InChI Key InChIKey=BMUSKHUHESQMIP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50666851   

TargetCyclin-dependent kinase 13/Cyclin-K(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666851BDBM50666851(CHEMBL6176040)
Affinity DataIC50: 79nMAssay Description:Inhibition of CDK13/Cyclin K (unknown origin) using pS7-CTD peptide and ATP as substrate incubated for 120 mins by ADP-Glo reagent based luminescence...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666851BDBM50666851(CHEMBL6176040)
Affinity DataIC50: 107nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant CDK12/N-terminal FLAG and C-terminal 6X His-tagged Cyclin K expressed in HEP Sf9 cells using AT...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666851BDBM50666851(CHEMBL6176040)
Affinity DataIC50: 107nMAssay Description:Inhibition of CDK12/Cyclin K (unknown origin) using pS7-CTD peptide and ATP as substrate incubated for 120 mins by ADP-Glo reagent based luminescence...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666851BDBM50666851(CHEMBL6176040)
Affinity DataIC50: 111nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged CDK13/N-terminal FLAG and C-terminal His-tagged Cyclin K expressed in HEP Sf9 cells using ATP a...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50666851BDBM50666851(CHEMBL6176040)
Affinity DataIC50: 204nMAssay Description:Inhibition of human recombinant N-terminal 6X His-tagged CDK7/CCNH/N-terminal 6X His-tagged MNAT1 expressed in HEP Sf9 cells using ATP as substrate m...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666851BDBM50666851(CHEMBL6176040)
Affinity DataIC50: 641nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged CDK9/N-terminal GST-tagged and C-terminal 8X His-tagged Cyclin T1 expressed in HEP Sf9 cells us...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed