BDBM50666913 CHEMBL6174759

SMILES CCN1CCC(NC(=O)c2ccc(OCc3c(C)noc3C)c(OC)c2)CC1

InChI Key InChIKey=OMYHFYBKBHLXKI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50666913   

TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 402nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 855nMAssay Description:Antagonist activity at TLR8 in human THP1-Dual MD2-CD14-TLR4 cells assessed as inhibition of TL8-506 induced DMR signals preincubated with compound f...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 1.07E+3nMAssay Description:Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 7(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity at TLR7 in HEK-Blue hTLR7 cells assessed as inhibition of CL307 induced NF-kappaB activation preincubated with compound for 1 hrs...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed