BDBM50666915 CHEMBL6172807

SMILES COc1cc(C(=O)NCC(c2ccc(C)cc2)N(C)C)ccc1OCc1c(C)noc1C

InChI Key InChIKey=FVFVUGHEPITKDE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50666915   

TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666915BDBM50666915(CHEMBL6172807)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666915BDBM50666915(CHEMBL6172807)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666915BDBM50666915(CHEMBL6172807)
Affinity DataIC50: 1.15E+3nMAssay Description:Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 7(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666915BDBM50666915(CHEMBL6172807)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity at TLR7 in HEK-Blue hTLR7 cells assessed as inhibition of CL307 induced NF-kappaB activation preincubated with compound for 1 hrs...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed