BDBM50666953 CHEMBL6177465

SMILES C=CS(=O)(=O)N1CCC[C@@H](Nc2nc(N)nc(Nc3cccc(Oc4ccccc4)c3)n2)C1

InChI Key InChIKey=YPLTXPUCWWZIEY-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50666953   

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human BMX in the presence of ATP at Km concentration by caliper mobility shift assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 26nMAssay Description:Inhibition of TEC (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 177nMAssay Description:Inhibition of EGFR T790M (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 187nMAssay Description:Inhibition of BTK (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 392nMAssay Description:Inhibition of HER2 (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 437nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 468nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 638nMAssay Description:Inhibition of BLK (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HER4 (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666953BDBM50666953(CHEMBL6177465)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ITK (unknown origin) in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed