BDBM50668105 CHEMBL6188928

SMILES Cc1cc(Nc2nc(N(C)c3c(F)cc(S(N)(=O)=O)cc3F)nc(-c3cnn(C)c3)c2C2CC2)n[nH]1

InChI Key InChIKey=DMOMFDVGUKWTJU-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50668105   

TargetSerine/threonine-protein kinase PLK4(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668105BDBM50668105(CHEMBL6188928)
Affinity DataIC50: 6nMAssay Description:Binding affinity to NanoLuc-fused PLK4 (unknown origin) transfected in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Repare Therapeutics, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668105BDBM50668105(CHEMBL6188928)
Affinity DataEC50:  140nMAssay Description:Inhibition of PLK4 in human RPE1-hTERT Cas9 Dp53 DPAC cells assessed as centriole depletion incubated for 6 days by DAPI staining based immunofluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed