BDBM50668653 CHEMBL6192038

SMILES c1cc(ccc1CN2[C@H](CCn3c(cc(n3)Cc4cc(cc(c4)F)F)C2=O)CO)C(F)(F)F

InChI Key InChIKey=SZLZNFDCRGBJIA-UHFFFAOYSA-N

Data  3 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50668653   

TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668653BDBM50668653(CHEMBL6192038)
Affinity DataKd:  181nMAssay Description:Stabilization of human ClpP in human MDA-MB-231 cells assessed as melting temperature at 10 uM measured after 8 hrs by cellular thermal shift assay (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668653BDBM50668653(CHEMBL6192038)
Affinity DataKd:  181nMAssay Description:Binding affinity to human recombinant ClpP assessed as dissociation constant by microscale thermophoresis (MST) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668653BDBM50668653(CHEMBL6192038)
Affinity DataKd:  181nMAssay Description:Stabilization of human ClpP in human MOLM-13 cells assessed as melting temperature at 10 uM measured after 8 hrs by cellular thermal shift assay (CET...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668653BDBM50668653(CHEMBL6192038)
Affinity DataEC50:  220nMAssay Description:Agonist activity at human ClpP expressed in Escherichia coli BL21(DE3) using FITC-casein substrate assessed as fluorescence of FITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)