BDBM508330 1-(2-chlorophenyl)-7-cyclopropyl-4- (isoxazol-4-ylamino)quinazolin-2(1H)- one::US11046691, Compound 641::US11084798, Cpd No 641

SMILES Clc1ccccc1-n1c2cc(ccc2c(Nc2cnoc2)nc1=O)C1CC1

InChI Key InChIKey=PWJDERZZSYANCM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 508330   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508330(US11046691, Compound 641 | 1-(2-chlorophenyl)-7-cy...)
Affinity DataIC50: 200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM508330(US11046691, Compound 641 | 1-(2-chlorophenyl)-7-cy...)
Affinity DataIC50: 200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent