BDBM5093 1,2,4-Oxadiazole Analogue 4f::4-[(2S)-2-{[(1S)-3-carbamoyl-1-{3-[(3,4-dichlorophenyl)methyl]-1,2,4-oxadiazol-5-yl}propyl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid

SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(Cl)c(Cl)c2)no1

InChI Key InChIKey=HKOHWDTYCZDWEW-PMACEKPBSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5093   

TargetTyrosine-protein kinase ZAP-70(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5093(1,2,4-Oxadiazole Analogue 4f | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  1.40E+4nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGrowth factor receptor-bound protein 2(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5093(1,2,4-Oxadiazole Analogue 4f | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  4.41E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase SYK(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5093(1,2,4-Oxadiazole Analogue 4f | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

LigandPNGBDBM5093(1,2,4-Oxadiazole Analogue 4f | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  2.06E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed