BDBM511450 US11059784, Example 58

SMILES C\C(=N/OCc1ccc(C2CCCCC2)c(c1)C(F)(F)F)c1ccc(cc1)C(=O)N1CCC(N)(COP(O)(O)=O)CC1

InChI Key InChIKey=TVZLXRFHJUYMQU-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 511450   

TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM511450(US11059784, Example 58)
Affinity DataIC50: 10.7nMAssay Description:Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1×109 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM511450(US11059784, Example 58)
Affinity DataEC50:  60.8nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in an 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or ED...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM511450(US11059784, Example 58)
Affinity DataEC50: >3.13E+3nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in an 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or ED...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent