BDBM511474 US11059789, Example 23::US11691950, Example 23

SMILES CN(C)C(C(=O)Nc1ccc2cnccc2c1)c1ccc(COC(=O)CCC(=O)OCC(=O)[C@@]23OC(C)(C)O[C@@H]2C[C@H]2[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]32C)cc1

InChI Key InChIKey=UDLFKDHOQVRFSO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511474   

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511474(US11059789, Example 23 | US11691950, Example 23)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511474(US11059789, Example 23 | US11691950, Example 23)
Affinity DataIC50: 4.5nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent