BDBM511486 US11059789, Example 19::US11691950, Example 19

SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)COC(=O)C1CC1C(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1

InChI Key InChIKey=HSRYETVWRVWJQQ-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 511486   

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 27nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 27nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 58nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 58nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 332nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 332nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetProtein kinase C eta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 436nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C alpha type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 436nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 589nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C delta type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 589nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 2.54E+3nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 2.57E+3nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C epsilon type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetProtein kinase C epsilon type(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 4.16E+3nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 9.57E+3nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 9.57E+3nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 1.38E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 5.00E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 5.00E+4nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM511486(US11059789, Example 19 | US11691950, Example 19)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent