BDBM511528 3-fluoro-4-piperidin-4- ylsulfanylbenzenesulfonamide hydrochloride (intermediate 8)/ 3-[2-[(5-methyltetrazol-2- yl)methyl]-4-(trifluoromethyl)- phenyl]propanoic acid (CAS- RN 1646783-83-6)::US11059794, Example 5.01::US11059794, Example 7.00::US11059794, Example 8.00

SMILES Cc1nnn(Cc2cc(ccc2CCC(=O)N2CCC(CC2)Sc2ccc(cc2F)S(N)(=O)=O)C(F)(F)F)n1

InChI Key InChIKey=RJDGGCMPSZYTGD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 511528   

TargetAtaxin-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM511528(3-fluoro-4-piperidin-4- ylsulfanylbenzenesulfonami...)
Affinity DataIC50:  4nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAtaxin-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM511528(3-fluoro-4-piperidin-4- ylsulfanylbenzenesulfonami...)
Affinity DataIC50:  5nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAtaxin-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM511528(3-fluoro-4-piperidin-4- ylsulfanylbenzenesulfonami...)
Affinity DataIC50:  3nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM511528(3-fluoro-4-piperidin-4- ylsulfanylbenzenesulfonami...)
Affinity DataIC50:  20.7nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent