BDBM513289 3-oxa-6-azabicyclo[3.1.1]heptan-6-yl(6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-yl)methoxy)pyridazin-3-yl)methanone::US11091471, Example 157::US20240279218, Example 157

SMILES Cc1onc(c1COc1ccc(nn1)C(=O)N1C2CC1COC2)-c1ccc(C)nc1

InChI Key InChIKey=GXAQMBSYBNUQQZ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 513289   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513289(3-oxa-6-azabicyclo[3.1.1]heptan-6-yl(6-((5-methyl-...)
Affinity DataKi:  6nMAssay Description:The affinity of compounds at GABAA receptor subtypes was measured by competition for [3H]flumazenil (85 Ci/mmol; Roche) binding to HEK293 cells expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513289(3-oxa-6-azabicyclo[3.1.1]heptan-6-yl(6-((5-methyl-...)
Affinity DataKi:  6nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent