BDBM513991 US11059827, Compound TSR-011

SMILES CC(C)NC(=O)C1CCC(n2c(NC(=O)c3ccc(F)cc3)nc3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1

InChI Key InChIKey=WSTUJEXAPHIEIM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 513991   

TargetHigh affinity nerve growth factor receptor(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 513991BDBM513991(US11059827, Compound TSR-011)
Affinity DataIC50: 2.30nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent