BDBM515306 6-(1-cyclopropyl-1H-1,2,4- triazol-5-yl)-4-ethyl-2- {(2R)-2-hydroxy-2-[(3S)- 1,2,3,4- tetrahydroisoquinolin-3- yl]ethyl}-3,4- dihydroisoquinolin-1(2H)- one::US11098059, Example 10

SMILES CCC1CN(C[C@@H](O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)-c1ncnn1C1CC1

InChI Key InChIKey=MKFVJVPIFLNNNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515306   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515306(US11098059, Example 10 | 6-(1-cyclopropyl-1H-1,2,4...)
Affinity DataIC50: 0.400nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515306(US11098059, Example 10 | 6-(1-cyclopropyl-1H-1,2,4...)
Affinity DataIC50: 374nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent