BDBM515308 4-ethyl-2-{2-hydroxy-2-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-yl]ethyl}-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-ylcarbonyl)-3,4-dihydroisoquinolin-1(2H)-one::US11098059, Example 12

SMILES CCC1CN(CC(O)[C@@H]2Cc3ccccc3CN2)C(=O)c2ccc(cc12)C(=O)N1C2CCC1COC2

InChI Key InChIKey=LPPKXBXXUDNWIG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515308   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515308(US11098059, Example 12 | 4-ethyl-2-{2-hydroxy-2-[(...)
Affinity DataIC50: 0.630nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM515308(US11098059, Example 12 | 4-ethyl-2-{2-hydroxy-2-[(...)
Affinity DataIC50: 253nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a twenty-point (1:2 serial dilution; top compound concentration of 100000 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent