BDBM515368 (13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1(5,3)- pyrazolo[1,5-a]pyrimidine- 3(3,2)-pyridine-2(1,2)- pyrrolidylcyclooctanephane-8-one::US11098060, Example 27

SMILES Nc1nn2ccc3nc2c1C(=O)NCCCc1ncc(F)cc1[C@H]1C[C@H](F)CN31

InChI Key InChIKey=GUZHFMMIDPYXCX-SMDDNHRTSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 515368   

TargetHigh affinity nerve growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515368((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...)
Affinity DataIC50:  0.210nMAssay Description:A testing platform for TrkAWT kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515368((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...)
Affinity DataIC50:  0.680nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetHigh affinity nerve growth factor receptor [G667C](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515368((13E,14E,22R,24S)-12-amino- 24,35-difluoro-7-aza-1...)
Affinity DataIC50:  1.89nMAssay Description:TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells by using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent