BDBM515457 N-(2-(4-methylpiperazin-1-yl)-5-(7-oxo-7,8,9,10-tetrahydrocyclopenta[4,5]pyrrolo[2,3-f]isoquinolin-2-yl)phenyl)acrylamide::US11098061, Compound II-e-4

SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)C=C)-c1cc2c3[nH]c4CCC(=O)c4c3ccc2cn1

InChI Key InChIKey=DPVLYBHPRDWKEE-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 515457   

TargetMAP kinase-activated protein kinase 2(Human)
Celgene Car

US Patent
LigandPNGBDBM515457(US11098061, Compound II-e-4 | N-(2-(4-methylpipera...)
Affinity DataIC50: 100nMAssay Description:Briefly, a 1.25× stock of MK-2 enzyme from Invitrogen (PV3317), a 5× stock of ATP (AS001A), and ST3-Sox peptide substrate (KNZ1031C) were prepared in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetMAP kinase-activated protein kinase 2(Human)
Celgene Car

US Patent
LigandPNGBDBM515457(US11098061, Compound II-e-4 | N-(2-(4-methylpipera...)
Affinity DataEC50: <100nMAssay Description:Briefly, a 1.25× stock of MK-2 enzyme from Invitrogen (PV3317), a 5× stock of ATP (AS001A), and ST3-Sox peptide substrate (KNZ1031C) were prepared in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent