BDBM515742 US11053219, Example 147::US11731956, Example 147

SMILES CNC(=O)c1nnc(cc1Nc1nccc(-c2ncn(C)n2)c1OC)N1CCN(C(C)C)C1=O

InChI Key InChIKey=RHVSHKXXVLQMQN-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 515742   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Alumis

US Patent
LigandPNGBDBM515742(US11053219, Example 147 | US11731956, Example 147)
Affinity DataKd: <1nMAssay Description:Developed by DiscoverX, KINOMEscan employs proprietary active-site dependent competition binding assays to determine how compounds bind to kinases. K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Alumis

US Patent
LigandPNGBDBM515742(US11053219, Example 147 | US11731956, Example 147)
Affinity DataKd: <1nMAssay Description:DiscoverX's KINOMEscan™ is a popular platform for kinase profiling, frequently used in academic and industry witnessed by publications, ther...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Esker Therapeutics

US Patent
LigandPNGBDBM515742(US11053219, Example 147 | US11731956, Example 147)
Affinity DataKd: <100nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Esker Therapeutics

US Patent
LigandPNGBDBM515742(US11053219, Example 147 | US11731956, Example 147)
Affinity DataKd: <100nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Alumis

US Patent
LigandPNGBDBM515742(US11053219, Example 147 | US11731956, Example 147)
Affinity DataKd: >1.00E+4nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Alumis

US Patent
LigandPNGBDBM515742(US11053219, Example 147 | US11731956, Example 147)
Affinity DataKd: >1.00E+4nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent