BDBM515745 US11053219, Example 166::US11731956, Example 166

SMILES COc1c(Nc2cc(NC(=O)C3CC3)ncc2C(=O)C2CC2)nccc1-c1ncn(C)n1

InChI Key InChIKey=SYCMDMZYGLCSGH-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 515745   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Alumis

US Patent
LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd: <1nMAssay Description:Developed by DiscoverX, KINOMEscan employs proprietary active-site dependent competition binding assays to determine how compounds bind to kinases. K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
US Patent

LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd: <1nMAssay Description:Streptavidin-coated magnetic beads were treated with biotinylated small molecule ligands for 30 minutes at room temperature to generate affinity resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Alumis

US Patent
LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd: <1nMAssay Description:DiscoverX's KINOMEscan™ is a popular platform for kinase profiling, frequently used in academic and industry witnessed by publications, ther...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Alumis

US Patent
LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd: <100nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Alumis

US Patent
LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd: <100nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Alumis

US Patent
LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd: <100nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Alumis

US Patent
LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd:  5.50E+3nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [866-1054](Human)
Alumis

US Patent
LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd:  5.50E+3nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Alumis

US Patent
LigandPNGBDBM515745(US11053219, Example 166 | US11731956, Example 166 ...)
Affinity DataKd:  5.50E+3nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent