BDBM516986 (S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amino)-1H- pyrazolo[3,4-b]pyridin-4- yl)oxy)phenyl)-2-(4- fluorophenyl)-3-oxo-2,3- dihydropyridazine-4- carboxamide::US11104676, Example 56

SMILES CC[C@@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4ccnn(-c5ccc(F)cc5)c4=O)cc3F)c12

InChI Key

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 516986   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  1.50E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  3.50E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  2.07E+4nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  2.90nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [1-13,15-1390](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  8.40nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230S](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  3.20nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [D1228N](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  3.40nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [F1200I](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  3.60nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [L1195V](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  75.8nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230C](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230H](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  4.90nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [D1228H](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516986((S)-N-(3-fluoro-4-((3-((1- hydroxybutan-2- yl)amin...)
Affinity DataIC50:  14.8nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent