BDBM517576 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-(3-(4-isopropyl-4H-1,2,4-triazol-3-yl)phenyl)picolinamide::USRE48711, Example 184

SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc(ccn2)-n2cnc(c2)C2CC2)c1

InChI Key InChIKey=UIZCAIJJBDQQHD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 517576   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM517576(USRE48711, Example 184 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM517576(USRE48711, Example 184 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 20nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM517576(USRE48711, Example 184 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 7.38E+3nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed