BDBM518424 6-[1-[1-(2-Aminoacetyl)-4-piperidyl]pyrazol-4-yl]-2-[(2S)-2-methylazetidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile::US11124500, Example 18

SMILES C[C@H]1CCN1c1nc(cc(c1C#N)C(F)(F)F)-c1cnn(c1)C1CCN(CC1)C(=O)CN

InChI Key InChIKey=MUNUHSBMSXYFGB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 518424   

TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518424(US11124500, Example 18 | 6-[1-[1-(2-Aminoacetyl)-4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518424(US11124500, Example 18 | 6-[1-[1-(2-Aminoacetyl)-4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518424(US11124500, Example 18 | 6-[1-[1-(2-Aminoacetyl)-4...)
Affinity DataIC50: 16nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Eli Lilly

US Patent
LigandPNGBDBM518424(US11124500, Example 18 | 6-[1-[1-(2-Aminoacetyl)-4...)
Affinity DataIC50: 35.6nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518424(US11124500, Example 18 | 6-[1-[1-(2-Aminoacetyl)-4...)
Affinity DataIC50: 59.2nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent