BDBM518821 US11117902, Example 3B::US11634426, Example 3A

SMILES Oc1ccc2c3[C@H](Oc4cc(Cl)ccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1

InChI Key InChIKey=HPRZXPUOMAQVBB-MUUNZHRXSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 518821   

TargetEstrogen receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM518821(US11117902, Example 3B | US11634426, Example 3A)
Affinity DataKi:  0.590nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM518821(US11117902, Example 3B | US11634426, Example 3A)
Affinity DataKi:  2.79nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEstrogen receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM518821(US11117902, Example 3B | US11634426, Example 3A)
Affinity DataKi:  8.11nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEstrogen receptor [Y537S](Human)
Eli Lilly

US Patent
LigandPNGBDBM518821(US11117902, Example 3B | US11634426, Example 3A)
Affinity DataKi:  27.2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent