BDBM519648 US11142525, Example 49

SMILES CNCc1nc(cc2C(=O)N(Cc12)c1cccc(n1)N1[C@@H](C)COC1=O)C1(C)CC1

InChI Key InChIKey=ZOYAGYCUGBXRJM-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 519648   

LigandPNGBDBM519648(US11142525, Example 49)
Affinity DataKi:  1.46nMAssay Description:HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay (MSA). The reactions were conducted in 50 μL volumes in 96-well pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

LigandPNGBDBM519648(US11142525, Example 49)
Affinity DataKi:  1.5nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition constant in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM519648(US11142525, Example 49)
Affinity DataIC50: 730nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed