BDBM519989 2-(4-(6-((S)-7-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)-3-oxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl)pyridin-3-yl)phenyl)-2-methylpropionic acid::US11142527, Example 19

SMILES COC(=O)C1=C(CN2CCN3C(=O)N(c4ccc(-c5ccc(C(C)(C)C(=O)O)cc5)cn4)C[C@@H]3C2)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Cl

InChI Key InChIKey=LMBADEAIDCZGRS-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 519989   

TargetLarge envelope protein(HBV-D)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 519989BDBM519989(2-(4-(6-((S)-7-(((R)-6-(2-chloro-4-fluorophenyl)-5...)
Affinity DataEC50:  14nMAssay Description:8000 HepG 2.2.15 cells per well were seeded into a 96-well plate, the plate was cultured at 37° C. and 5% CO2 for 3 days till the cells grew to full ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent