BDBM520018 (R)-methyl 4-(2-chloro-4-fluorophenyl)-6-(((S)-2-(4-(4-(morpholine-4-carbonyl) phenoxy)phenyl)-3-oxohexahydroimidazo[1,5-a]pyrazin-7(1H)-yl)methyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate::US11142527, Example 56

SMILES COC(=O)C1=C(CN2CCN3C(=O)N(c4ccc(Oc5ccc(C(=O)N6CCOCC6)cc5)cc4)C[C@@H]3C2)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Cl

InChI Key InChIKey=QAVKTQYPZGQAGA-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 520018   

TargetLarge envelope protein(HBV-D)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 520018BDBM520018((R)-methyl 4-(2-chloro-4-fluorophenyl)-6-(((S)-2-(...)
Affinity DataEC50:  12.4nMAssay Description:8000 HepG 2.2.15 cells per well were seeded into a 96-well plate, the plate was cultured at 37° C. and 5% CO2 for 3 days till the cells grew to full ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent