BDBM521182 7-(2-fluoro-4- hydroxy- phenyl)-8-[4- [(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]- 5,6- dihydronaphtha- len-2-ol::US11149031, Example 6

SMILES Oc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3cc(O)ccc3CC2)c(F)c1

InChI Key InChIKey=AMMZUTQIWBWTQO-DEOSSOPVSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521182   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521182(7-(2-fluoro-4- hydroxy- phenyl)-8-[4- [(3S)-1-(3- ...)
Affinity DataIC50:  2nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521182(7-(2-fluoro-4- hydroxy- phenyl)-8-[4- [(3S)-1-(3- ...)
Affinity DataIC50:  8nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521182(7-(2-fluoro-4- hydroxy- phenyl)-8-[4- [(3S)-1-(3- ...)
Affinity DataIC50:  13nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent