BDBM521270 4-(2-fluoro-4- hydroxy- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]- 2,3-dihydro-1- benzoxepin-8- ol::US11149031, Example 94

SMILES Oc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2OCC1

InChI Key InChIKey=NPWJKNXDBDURRN-QHCPKHFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521270   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521270(4-(2-fluoro-4- hydroxy- phenyl)-5-[4- [(3S)-1-(3- ...)
Affinity DataIC50:  2nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521270(4-(2-fluoro-4- hydroxy- phenyl)-5-[4- [(3S)-1-(3- ...)
Affinity DataIC50:  6nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521270(4-(2-fluoro-4- hydroxy- phenyl)-5-[4- [(3S)-1-(3- ...)
Affinity DataIC50:  10nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent