BDBM521414 6-(2,4- dichlorophenyl)- 5-[2-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxypyrimidin- 5-yl]-8,9- dihydro-7H- benzo[7]annulen- 2-ol::US11149031, Example 238

SMILES Oc1ccc2c(c1)CCCC(c1ccc(Cl)cc1Cl)=C2c1cnc(O[C@H]2CCN(CCCF)C2)nc1

InChI Key InChIKey=WNUSNGDMRGNYDQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521414   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 521414BDBM521414(6-(2,4- dichlorophenyl)- 5-[2-[(3S)-1-(3- fluoropr...)
Affinity DataIC50: 3nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 521414BDBM521414(6-(2,4- dichlorophenyl)- 5-[2-[(3S)-1-(3- fluoropr...)
Affinity DataIC50: 33nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 521414BDBM521414(6-(2,4- dichlorophenyl)- 5-[2-[(3S)-1-(3- fluoropr...)
Affinity DataIC50: 59nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent