BDBM522284 US11161839, Example 10e

SMILES CC(Nc1cc(=O)n(C)c2ccc(Nc3ccnc(Cl)c3C#N)cc12)c1ncc(cn1)C1CC1

InChI Key InChIKey=FHLDBZWADXDVDT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 522284   

TargetB-cell lymphoma 6 protein [5-129](Homo sapiens (Human))
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM522284(US11161839, Example 10e)
Affinity DataIC50:  53.7nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained either 1 nM (data in table 1b) or 10 nM (data in table 1a) Trx-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522284(US11161839, Example 10e)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of human nanoLuc-tagged BCL6 expressed in HEK293T cells coexpressing HaloTag-SMRT using NanoBRET furimazine substrate incubated for 6 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522284(US11161839, Example 10e)
Affinity DataIC50:  54nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed