BDBM524061 US11136336, Example 12

SMILES Cc1c(sc2ncn(Cc3nc(C[C@H](O)c4ccc(Cl)cc4)no3)c(=O)c12)C(=O)NCC(F)F

InChI Key InChIKey=CBZINAVQQWCRAE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 524061   

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM524061(US11136336, Example 12)
Affinity DataIC50: 15nMAssay Description:At the assay day cells were washed 3× with assay puffer, 20 μL buffer remained in the wells after washing. 10 μL Ca6 kit (Cat.R8191 Molecul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM524061(US11136336, Example 12)
Affinity DataIC50: 15nMAssay Description:Antagonist activity against human TRPA1 expressed in HEK293K cells assessed as inhibition of AITC-induced intracellular calcium accumulation measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed