BDBM524387 4-(5-(4-(dimethylamino)phenyl)-1- (piperidin-4-ylmethyl)-1H-pyrrolo[2,3- c]pyridin-4-yl)benzonitrile::US11168082, Cpd. No. 85

SMILES CN(C)c1ccc(cc1)-c1ncc2n(CC3CCNCC3)ccc2c1-c1ccc(cc1)C#N

InChI Key InChIKey=ZDXOPHYHWORTAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 524387   

TargetLysine-specific histone demethylase 1A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM524387(US11168082, Cpd. No. 85 | 4-(5-(4-(dimethylamino)p...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli using H3K4me2 peptide as substrate incubated for 60 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM524387(US11168082, Cpd. No. 85 | 4-(5-(4-(dimethylamino)p...)
Affinity DataIC50: 23.1nMAssay Description:Human recombinant LSD1 protein expressed in E. coli cells was purchased from Active Motif (Carlsbad, Calif.). Biotin-labeled Histone H3K4Me peptide (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent