BDBM525728 US11174252, Compound 23

SMILES CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(nc2)N2CCNCC2)ncc1F

InChI Key InChIKey=BPMAUJVZZZYXDV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 525728   

TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525728(US11174252, Compound 23)
Affinity DataIC50:  2nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM525728(US11174252, Compound 23)
Affinity DataIC50:  4.89E+3nMAssay Description:PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 mM (pH7.5), Orthovanadate 3 mM, MgCl2 20 mM, DTT 2 mM, CHAPS 0.05%, DMSO 1%). PI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525728(US11174252, Compound 23)
Affinity DataIC50:  25nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525728(US11174252, Compound 23)
Affinity DataIC50:  2nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent