BDBM525739 US11174252, Compound 34

SMILES CN1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1F

InChI Key InChIKey=ZXZSDNZHOPWUFI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525739   

TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525739BDBM525739(US11174252, Compound 34)
Affinity DataIC50: 3nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525739BDBM525739(US11174252, Compound 34)
Affinity DataIC50: 6nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525739BDBM525739(US11174252, Compound 34)
Affinity DataIC50: 42nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent