BDBM525752 US11174252, Compound 439

SMILES CC(C)N1CCOc2c(Cl)cc(cc12)-c1nc(Nc2ccc(N3CCNCC3)c(F)c2)ncc1F

InChI Key InChIKey=RHWSILDHCUHQSO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525752   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525752BDBM525752(US11174252, Compound 439)
Affinity DataIC50: 6nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525752BDBM525752(US11174252, Compound 439)
Affinity DataIC50: 7.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 525752BDBM525752(US11174252, Compound 439)
Affinity DataIC50: 20nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent